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Three authors (K.B., C.B., and L.M.) independently searched MEDLINE, Embase, and PsychINFO from 1960 (or 1974 in the case of EMBASE) to March 30th 2023, identifying 159 papers in total (111 with duplicates removed)

Bain et al

Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by Health promoting factors

Checking GLP-1 levels helps doctors see how well the body makes insulin

Conclusion The current evidence suggests a possible association between use of GLP-1RA and an increased risk of depression, but overall risk seems to be dominated by population characteristics, drug class, and how mood outcomes are assessed