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doi: 10.1038/s41598-020-57506-9

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Drug Interaction for the day Fluoxetine (an SSRI) + Tramadol (an opioid analgesic with serotonergic activity) can significantly increase the risk of serotonin syndrome

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But understanding that the labels reflect an absence of data rather than the presence of danger is important context for any mother evaluating her options with her healthcare provider