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The -ketoglutarate dehydrogenase complex (KGDHC) is a three-enzyme complex that catalyzes the oxidation of -ketoglutarate to succinic acid and is a rate-regulating enzyme for the TCA cycle

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Smaller, more defined pockets of fat also tend to show results faster than larger, more diffuse areas

It has also been the subject of much discussion regarding its use for weight loss

While berberine may offer modest metabolic benefits, it works through different mechanisms and produces smaller glycemic improvements than prescription GLP-1 medications, which remain the evidence-based standard of care