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Response: We do not agree that CPT code 64596 is an outlier in assigning the MPPR status to Y in that many other surgical procedures with significant device costs in the Neurostimulator and Related Procedures APC clinical family are also discounted under the MPPR policy, such as CPT code 64583 (Revision or replacement of hypoglossal nerve neurostimulator array and distal respiratory sensor electrode or electrode array, including connection to existing pulse generator)

Common side effects include nausea, vomiting, diarrhea, constipation, and fatiguetypically mild and transient during dose escalation

MPNST are rare and highly aggressive

Nevertheless, GLP-1RA therapy is associated with a pattern of adverse events affecting their safety and tolerability

Efficacy and safety of retatrutide in people with type 2 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 1b trial