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In conclusion, this post hoc analysis of SURMOUNT1 trial data demonstrated that the vast majority (90%) of those who had less than a 5% weight reduction by Week 12 of tirzepatide treatment ultimately had a clinically meaningful (5%) weight reduction by Week 72 and being on a higher dose of tirzepatide was associated with greater weight reduction, even for late responders

Processing of wild-type and mutant proinsulin-like growth factor-IA by subtilisin-related proprotein convertases