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She points out that obesity, itself, is a severe and chronic disease that carries a high risk for heart disease, strokes, fatty liver disease that could lead to liver cancer, as well as diabetes that can result in kidney disease

It was next investigated whether the underlying mechanisms involved reduced proliferation, altered cell cycle progression or increased cell death, possibly due to enhanced DNA damage

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The meta-score was computed as the geometric mean of the expression of biomarker genes (when only genes up-regulated in cases vs