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In vivo inhibition of serine protease processing requires a high fractional inhibition of cathepsin C

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Triagonist increases GSIS in primary islets To assess the effects of the triagonist and mono-agonists on GSIS, single islets from WT mice fed an LFD were exposed to a switch from low glucose (2.8 mmol/l) to high glucose (20 mmol/l), with or without agonists

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doi:10.1016/j.bbamcr.2016.01.023 Talenezhad, N., Mohammadi, M., Ramezani-Jolfaie, N., Mozaffari-Khosravi, H., & Salehi-Abargouei, A