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This leads to a reduction in ovarian reserve and a higher occurrence of chromosomal abnormalities especially aneuploidy in oocytes 3,4 , increasing the risks of infertility, pregnancy loss, perinatal mortality, and congenital disorders in women at an advanced age 5,6

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Conversely, erastin- and TGF-1-treated lung fibroblasts presented increased activation and differentiation and accelerated the fibrosis process [227]