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Studies have shown that the expression of inflammatory markers such as Tumor Necrosis Factor alpha (TNF-a) and Interleukin-6 (IL-6) significantly diminish when there are high cellular levels of NAD+ and its precursors

Oral drugs undergo what is known as first-pass metabolism. First-pass metabolism is when the concentration of a drug, specifically when administered orally, is significantly reduced before it reaches systemic circulation

Since antioxidants have been shown to lower oxidative stress markers, it can be assumed that they will be helpful in the prevention and treatment of these disorders

This is where the evidence gradient matters

10.1104/pp.015891 551 StairR.CoblentzW