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The 2004 Bissett study in International Journal of Cosmetic Science used twice-daily 5 percent niacinamide for 12 weeks in 50 women aged 40 to 60, documenting significant reductions in fine lines, hyperpigmentation spots, blotchiness, and yellowing [13]

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As a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA), tirzepatide produces synergistic effects like increased insulin production and release, which gives it an edge over strict GLP-1 receptor agonist such as semaglutide (Ozempic)

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