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Surg Pathol Clin 14:165175 Padilla-Rodrguez AL, Bembassat M, Lazaro M, Ortiz-Hidalgo C (2007) Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis
That said, in a mouse study, supplementation with L-carnitine (400 mg/kg/day for 8 weeks) allowed to reduce weight gain induced by time-shifted feeding, a model mimicking certain effects of a disorganized lifestyle
Note additionally that the three methionine residues in the sequence, two of them in the N-terminal extension, make dilute standing solution vulnerable to oxidation, and that freeze-thaw cycling promotes aggregation in disulfide-bonded proteins more readily than in short peptides
Restricting cysteine, depleting GSH, or inhibiting GPX4 can increase phospholipid peroxidation in responsive cells, but sensitivity also depends on lipid composition, iron metabolism, parallel antioxidant systems, and tissue context (Jiang et al., 2021)
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