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The medication also appears to influence areas of the brain involved in reward and food intake regulation

In animal studies, rats exposed to GLP-1 receptor agonists at high doses over their lifetimes developed C-cell tumors, including medullary thyroid carcinoma (MTC)

Glucagon-like peptide 1 (GLP-1) secretion and plasma dipeptidyl peptidase IV (DPP-IV) activity in morbidly obese patients undergoing biliopancreatic diversion