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PMID 21424583

GCL belongs to the class of proteins that are sensitive to oxidative stress, and its expression is mainly under the regulation of the Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), a transcription factor that regulates a wide array of antioxidant responsive element-driven genes in various cell types ( the novo GSH biosynthesis is glutathione synthase (GS)

While often highlighted, skin radiance is a natural outcome of these deeper health benefits

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A comparative analysis of two pivotal studies highlights key parameters influencing therapeutic outcomes