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Alcohol consumption also remains an intractable risk factor, with heavy, long-term use contributing significantly to HCC and accounting for 30% of HCC cases and HCC-specific deaths (Patel and Mueller, 2025)

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Giannantoni A, Mearini E, Del Zingaro M et al: Two-year efficacy and safety of botulinum a toxin intravesical injections in patients affected by refractory painful bladder syndrome

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