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Even with coverage, copays and restrictions vary, so verifying benefits early helps avoid delays during dose escalation

Specific Issues Semaglutide : Possibly has a slightly increased rate of gastrointestinal discomfort Tirzepatide : As it is newer, long-term data are still in the process of emerging, but initial studies report a tolerable side effect profile Serious Risks (Rare) Pancreatitis Gallbladder disease Risk of thyroid C-cell tumors (observed in rodent studies) Note: These drugs should not be administered in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2)

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