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Gelfand ST et al

Diagnosis typically involves a combination of patient history, clinical examination, and sometimes imaging or laboratory tests

The enzyme carbamoyl phosphate synthetase II (CPSII) uses glutamine to synthesize carbamoyl phosphate, a precursor for pyrimidine production

2026 shows that in osteoarthritis, cartilage cells (chondrocytes) tend to run in a stressed, inefficient low-gear mode, but when semaglutide is introduced (in a mouse model), those cells shift into a healthier, more efficient energy state