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A similar pattern was seen in microbial hydrolysis of GRP in RCM medium (supports the growth of clostridia, bifidobacteria, and others) with 0.5 mM GRP, but only at a 12 h time point

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However, chronic GLP-1 receptor activation, which better mimics what happens with a weekly medication like tirzepatide, did not consistently produce anxiety-like behavior and in some models actually reduced depression-like behavior

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