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Key points Obesity is a risk factor for developing osteoarthritis (OA), gout, rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA), and is associated with higher disease activity and/or severity, and worse response to common treatments
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Receptor crosstalk and combined signaling: Exploring whether simultaneous activation of two upstream pathways produces additive or synergistic signaling patterns in functional assays (model-dependent and protocol-specific)
GHK-Cu has been investigated for its role in controlling oxidative stress, extracellular matrix turnover, and gene expression modulation