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Persistence through the escalation phase predicts long-term tolerance

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Rachel Sorvig, a spokesperson for Zepbound and Mounjaro manufacturer Eli Lilly, said in a statement that users should talk to their health care provider about dosage and duration needs. Studies have shown that people typically regain a substantial amount of weight within a year of stopping GLP-1 medications, and that many people who quit ultimately go back on the drugs

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Clinical trial data suggests roughly similar rates, though individual experiences vary widely