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61 A working core outcome set for CLE trials was recently developed to guide future clinical and outcomes research in CLE, recommending the CLASI as a primary endpoint and the Cutaneous Lupus Activity IGA (CLA-IGA) as a secondary endpoint for CLE physician-reported outcome measures

IR, a hallmark of PCOS, is characterized by a reduction in the effectiveness of insulin transduction and impaired epimerase activity, which limits the release of DCI from muscle and adipose tissue (138)