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Variant CJD is acquired by ingestion of meat from cattle afflicted by bovine spongiform encephalopathy, with the BSE prion crossing the species barrier and misfolding native human brain PrP c

doi: ..10.1056/NEJMe038104 [PubMed: 12890849] [CrossRef] 294

A large international, multicenter, double-blind, placebo-controlled trial, the Folic Acid Clinical Trial (FACT), was initiated to evaluate whether high-dose folic acid supplementation throughout pregnancy could prevent preeclampsia and other adverse outcomes (e.g., maternal death, placental abruption, preterm delivery) (76)

Based on the various types and complexities involved, its management and evaluation become quite challenging