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An additional exploratory analysis evaluated a composite outcome including bailout events, major adverse limb events (MALE), and mortality, showing a 54-% reduction in these events (hazard ratio [HR] 0.46, 95% confidence interval [CI] 0.24-0.84)

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HoltWinters models are used for forecasting data with changing trends and seasonal correlation, using triple exponential smoothing to account for three parameters: mean values (level), trend over time and seasonality

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Staying hot for too long during exercise can also cause fainting