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The phase 3 ESSENCE trial, a multicenter, randomized, double-blind, placebo-controlled study, included 1197 patients with biopsy-confirmed MASH and F2-F3 fibrosis, of whom 800 were analyzed interim after 72 weeks of treatment with semaglutide at a dose of 2.4 mg subcutaneously weekly or placebo (2:1)

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When all three hormones work together, studies describe a synergistic effect that supports weight loss through both appetite and energy use