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For example, inhibition of glycolysis via 2-DG can activate AMP-activated protein kinase, promoting autophagy as a survival mechanism [150]

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Notably, at physiological concentrations, TMAO can enhance the integrity of the bloodbrain barrier through the tight junction regulator annexin A1, limit the reactivity of astrocytes and microglia, and protect the cognitive function of mice from inflammatory challenges

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This study further denoted the importance of Apoe-Trem2 signaling pathway in connecting Apoe + mono-M and AMs