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(c) a reticulocyte response to B12 treatment

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My GP has (eventually) referred me to both a rheumatologist and an endocrinologist for further investigations, so perhaps that will throw some light on the matter

MOTS-c Before You Start: The Critical Protocol Facts MOTS-c is a mitochondria-derived peptide that regulates cellular energy metabolism, making it mechanistically distinct from every other peptide in clinical use today

Mechanism of Action Inhibits Nicotinamide N-Methyltransferase (NNMT) Increases intracellular nicotinamide and NAD levels Improves mitochondrial efficiency and energy metabolism Supports lipolysis and fat oxidation Reduces adipocyte (fat cell) growth and proliferation Modulates inflammatory pathways and insulin signaling These effects may lead to enhanced fat metabolism, better blood sugar regulation, improved endurance, and a general increase in metabolic flexibility