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4.4 Neuronal inflammatory response Under peripheral inflammatory conditions, the continuous release of inflammatory mediators may result in sustained activation of the neuronal inflammatory response, causing direct damage to neurons (Vasunilashorn et al., 2021)

Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion

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This makes GLP-1 receptor agonists particularly attractive for patients with obesity complicated by type 2 diabetes, establishing them as a cornerstone treatment option

Increasing attention has been given to emerging therapeutic strategies based on the paraptosis mechanism [125]