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Having objective data on key hormonal markers before, during, and after a research protocol is the gold standard for understanding a compound's true physiological impact

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10.1017/S0007114513000068 68 MikusN.MarszaekK.PodlachaM.IqbalA.PuchalskiC.wiergielA

In practice, stacking multiplies uncertainty: more compounds more chances of impurity/contamination more pathways affected more interaction risk more variables harder to know what helped (or harmed) If you take only one clinical principle from this article: the more experimental the stack, the more conservative your risk posture should be