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This is clearly demonstrated by experiments in which the administration of the neurotoxin MPTP, which blocks Complex I of the mitochondrial electron transport chain, induces characteristic features of PD in mice [56, 57]

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By integrating structural biology with metabolism, we aim to clarify when myelin is a resource to be tapped and to outline strategies to convert this insight into disease-modifying interventions

Diagnostic methods Glutathione and sulphydryl compunds in erythrocytes can be measured using 5,5'-dithiobis (2-nitrobenzoic acid), while glutathione in fibroblasts can be measured with the 5,5'-dithiobis (2-nitrobenzoic acid) glutathione recycling assay [16], or using high performance liquid chromatography (HPLC) [17]