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Timeline: What to Expect The table below maps the connective-tissue repair biology to what research (again, mostly animal research) has observed at each phase
Vitamin B12 is a water-soluble vitamin essential for red blood cell formation, neurological function, and DNA synthesis Requirements vary by age: infants need 0.30.4 mcg daily, children 0.51.2 mcg, and lactating women 2.0 mcg Pernicious anaemia typically requires intramuscular injections of 1,000 mcg hydroxocobalamin, initially three times weekly then every 23 months Deficiency causes macrocytic anaemia and neurological symptoms including paraesthesia, balance problems, and cognitive changes that may become irreversible B12 is found almost exclusively in animal products

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A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, 101 thereby being roughly four times higher than those in normal rats