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Specifically, the accumulation of misfolded CFTR in the endoplasmic reticulum (ER), as in the case of the F508del mutation, induces ER stress that fuels ROS production

doi: 10.1016/j.bone.2019.115197 52 IepsenEWLundgrenJRHartmannBPedersenOHansenTJorgensenNRet al

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Metformin should not be used by anyone who: Is pregnant or breastfeeding Has poor kidney or liver function Has hypoxia (low oxygen levels) Has acute or chronic metabolic acidosis, with or without coma Alternatives to Ozempic and metformin If you cannot take Ozempic, metformin, or both, there are alternatives for treating type 2 diabetes or losing weight that might be worth considering