Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer
A: It depends on your goal
Recent studies have focused on the proteomes of peripheral blood mononuclear cells (PBMCs) from ME/CFS patients, using Sequential Window Acquisition of All Theoretical Mass Spectra (SWATH-MS) for detailed protein analysis (Sweetman et al., 2020)
Saukkonen T, Shojaee-Moradie F, Williams RM, Amin R, Yuen KC, Watts A, Acerini CL, Umpleby AM, Dunger DB
The gut is not merely a digestive organit is a metabolic control center