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It is indicated for adults with a BMI of 30 kg/m or above, or a BMI of 27 kg/m or above with at least one weight-related comorbidity (such as type 2 diabetes, hypertension, or obstructive sleep apnoea)

Sources Jastreboff AM et al

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To ensure methodological clarity, avoid overstating analytical rigor and to address the inherent heterogeneity of comparing controlled clinical trials with observational real-world evidence, no original quantitative meta-analysis or formal risk-of-bias assessments were conducted