nNOS, neuronal nitric oxide synthase
While the gluten-free diet has been found to improve Hashimotos symptoms and reduce the autoimmune attack on the thyroid, its important to note that selenium deficiency can be caused or worsened by gluten and grain-free diets, as demonstrated in nutritional studies involving people with celiac disease
This substance can also reduce the oxidative stress (Lee et al., 2008) on SH-SY5Y (human dopaminergic neuron cells) by controlling the upregulation of Bax and the downregulation of Bcl-2, and reduce mitochondrial membrane potential by reducing reactive oxygen species
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In contrast, GSH depletion drives M1 polarization, resulting in heightened secretion of pro-inflammatory cytokines, including TNF-, IL-6, and IL-1 ( Overall, GSH helps limit unwanted immune attacks in the brain