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677972), the Netherlands Organisation for Scientific Research (NWO) Vidi award (no

Early-phase human trials are small, well-controlled studies centered on safety, reproductive hormones, and surrogate markers such as ovarian reserve tests and sperm parameters ahead of any efficacy trials

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A proof-of-concept trial investigating metformin as an add-on treatment for mild or moderate SLE demonstrated that metformin down-regulated the NETs mtDNA-PDC-IFN pathway, leading to clinical improvement of SLE and reduced its reliance on prednisolone (133)

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