Although the MR study used in this research can utilize genetic variations strongly correlated with exposure factors as instrumental variables to infer the causal effect between exposure factors and research outcomes, MR studies cannot replace randomized trials and should only serve as Supplementary material
Besides direct microbial killing, ROS are also involved in immune responses and emerging as central signaling molecules in the inflammatory response ( 2 Role of oxidative stress in AD Atopic dermatitis is a chronic inflammatory skin disease that commonly occurs in children (34)
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TMAO promotes macrophage infiltration and activation within adipose tissue, driving a shift in macrophage phenotype toward the pro-inflammatory M1 state, contributing to adipose tissue dysfunction, a key hallmark of obesity-related metabolic dysfunction [30, 75]
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