Intervention studies have shown that supplementation with riboflavin (the MTHFR cofactor) effectively lowers blood pressure, specifically in individuals with the variant MTHFR 677TT genotype
However, glutathione exists in various forms
Hormonal Balance DSIP has been studied for its effects on growth hormone release, cortisol regulation, and LH signalling making it of interest to researchers studying broader hormonal balance
This pathway induces the expression of various downstream target proteins, such as haem oxygenase 1 (HO-1), superoxide dismutase 1 (SOD1), quinone oxidoreductase 1 (NQO1), and glutamylcysteine synthetase (GCS), among others [97]
The majority of the studies (see above in red) are preclinical studies in rodents, the vast majority of which have been done by a single research group in Croatia, which has been rinsing and repeating the same approach for decades