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GLP-1RAs and SGLT2 inhibitors also have pleiotropic effects, including blood glucose-dependent and -independent mechanisms, effects on the reninangiotensinaldosterone system and favourable effects on left ventricular and renal functions [35, 36]

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Developed by researchers in Australia, AOD-9604 was initially investigated as a potential anti-obesity drug due to its ability to stimulate lipolysis (fat breakdown) and inhibit lipogenesis (fat accumulation)

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