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however, DNMT1 and DNMT3a remain expressed even in the largely post-mitotic adult brain, including the hippocampus (Feng et al., 2005)

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Signaling proteins directly or indirectly recruited to the phosphorylated docking site include the growth factor receptor-bound protein 2 (Grb2) adaptor, the non-receptor tyrosine kinase Src, Src homology 2 domain-containing (Shc) adaptor protein, the p85 subunit of phosphatidylinositol 3 kinase (PI3K), phospholipase C (PLC), tyrosine phosphatase SHP2, Src homology 2-containing inositol 5-phosphatase 1 (SHIP2), signal transducer and activator of transcription 3 (STAT3) and the multisubstrate docking protein Grb2-associated binding protein (Gab1) [57]

339 When GLP-1 binds to GLP-1R, it activates the cAMP signaling pathway, leading to increased cAMP levels