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it ranges from mild to severe and is constant, decadent it is characterized by epigastric pain radiating to the sides and chest

When the production of this pigment slows down, hair turns gray or white

doi: 10.33696/immunology.5.184 193 CaiYZhangJLiangJXiaoMZhangGJingZet al

Kim HJ, Miron VE, Dukala D, et al

Several mechanisms including glucotoxicity, lipotoxicity, altered secretion of adipokines/cytokines, hepatokines (mainly higher circulating fetuin-A levels), stimulation of multiple inflammatory pathways, reduced bile-acid synthesis, endoplasmic reticulum stress, increased oxidative stress, mitochondrial dysfunction and alterations in gut microbiota/gut-derived endotoxins, in a complex interplay with genetic predisposition, drive the evolution of inflammation, hepatocellular injury and fibrosis [2426]