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If your bottle delivers 0.12 mL per actuation and you calculate for 0.1 mL, every dose across your entire study is running 20% higher than your protocol intends

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Generally, weight loss of greater than 24% of initial body weight and at a rate greater than 1.5 kg (about 3.3 pounds) per week has been identified as a risk factor for gallstones, but the risk may be mitigated by controlling the rate of weight loss, reducing the length of the overnight fast, and keeping a small amount of fat (at least 7 grams per day) in the diet to improve gallbladder motility (Erlinger 2000)

Mechanisms of Central Nervous System Modulation 3.1

Nutrition experts recommend waiting at least 23 hours between snacks and main meals and limiting any single snack to a volume you can hold in one closed fist