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Two large RCTs, The Investigation for Maximal Peyronis Reduction Efficacy and Safety Studies (IMPRESS) I and II, examined the efficacy and safety of intralesional clostridial collagenase in the treatment of PD and obtained high-level evidence (Lipshultz et al., 2015)

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A study available on PubMed Central explores this connection, highlighting how the gut microbiomes composition can influence GLP-1 secretion and overall metabolic health

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