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It shares 94% sequence homology with human GLP-1 but has been structurally modified to resist rapid enzymatic breakdown, giving it a significantly extended half-life compared to native GLP-1

However, studies in LPS-primed murine bone marrowderived macrophages (BMDMs), D1 activation inhibits NLRP3 activity through a cAMP-dependent pathway, although D1-mediated increases in cAMP were not directly observed (Yan et al., 2015)

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This helps the body regulate insulin, among other things

Of note, improvements in glycemic control, blood pressure, and lipid profile have been identified, which may lead to a reduction or delay in disease progression