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Mechanistically, it was revealed that glutamine uptake effectively increased the concentration of tumor glutamine and its downstream metabolite -KG, which drove hypomethylation of H3K4me3 via JmjC-containing KDMs, resulting in the downregulation of epigenetically activated oncogenic pathways [89]

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10.1371/journal.pone.0032675 114

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However, the mechanism through which AZT inhibits complex I or succinate-linked respiration is still not clear

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