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These protocols should complement rather than replace appropriate medical evaluation and physical therapy

It is thought that over time, the population eligible under the new recommendations will fall slightly as the use of GLP-1s grows for other indications, the document adds

If taking insulin or sulfonylureas for diabetes, the dose of those medications may need to be lowered when starting Zepbound to reduce the risk of hypoglycemia (low blood sugar)

If meaningful results are occurring at 1.0 mg or 1.7 mg with acceptable tolerability, some protocols maintain that lower dose rather than continuing to escalate