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Study participants provided written informed consent and the study was undertaken according to Helsinki Declaration-II

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ophthalmologistdiagnosed retinopathy (non-proliferative retinopathy, proliferative retinopathy or a history of laser photocoagulation), nephropathy as evidenced by microalbuminuria (30300 mcg/day), or physician-diagnosed sensory polyneuropathy (by impaired vibration, crude touch, or monofilament perception)

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