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So far, studies on these new, multi-agonist drugs suggest that activating multiple receptors may lead to greater weight loss than GLP-1 alone

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At the same time, it is important to acknowledge the limitations of pivotal trials such as STEP and SELECT, whose generalisability is constrained by relatively short follow-up, notable dropout rates, and the predominance of Western cohorts

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We covered this earlier but it bears repeating in the context of constipation specifically