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For example, a recent study indicated that unlike in mouse islets where tirzepatide stimulates insulin secretion predominantly through the GLP-1R, the therapeutic effects of tirzepatide on human beta and alpha cells require engagement of both the GLP-1R and the GIPR, and in addition, tirzepatide increased glucagon secretion in isolated islets [207]

Central and peripheral administration of secretin inhibits food intake in mice through the activation of the melanocortin system

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PloS One 7 , e40318 (2012)