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Lab changes in IGF-1 may be seen earlier than visible changes.

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[16] [17] At a standard dose, paracetamol slightly reduces fever, [14] [18] [19] though it is inferior to ibuprofen in that respect: [20] the benefits of its use for fever are unclear, particularly in the context of fever of viral origins

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Finally, translational implications remain speculative because most interventions targeting mitochondrial or inter-organellar functions have been tested in prophylactic or early-treatment settings in animals, with little evidence regarding their efficacy, safety, and feasibility in established, severe disease in humans