Non-specific binding was defined by 100 nM of GLP-1(7-36) or human or mouse GIP(1-42)NH2
the authors explained that they then used propensity score matching based on whether the individuals received at least two prescriptions of a GLP-1 receptor agonist to create two comparable groups: one of 30,613 patients who had been prescribed a GLP-1 drug and one of equal size that did not
For many, the two approaches complement each other rather than compete
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Our results show pleiotropic anti-inflammatory and antioxidant effects that may mechanistically underlie the cardiovascular, hepatic, and renal protection consistently seen in large-scale cardiovascular outcome studies (45, 46), in addition to their well-established benefits on glycemic control and weight reduction (47, 48)
