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The systemic effects of AKI that may contribute to mortality have been extensively investigated in preclinical models

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Hamby ME, Coskun V, Sun YE (2008)

Sickle hemoglobin-containing red blood cells are tougher than regular red blood cells in circulation, in contrast to these alterations

After the first clinical report of APAP toxicity [22], investigators at the US National Institute of Health developed a mouse model of APAP-induced hepatotoxicity, which mimicked the serious liver injury observed in humans [79]